Route 222 southbound is closed near Route 100 in Trexlertown because of a truck fire as well as downed wires and a fuel spill, according to multiple reports.
There are heavy traffic delays and drivers are urged to avoid the area.
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State police on the scene are directing traffic off of Route 222 southbound onto Route 100.
The accident was first reported around 10:20 a.m. with heavy smoke showing in the area.
Occupants of the truck were able to get out safely, according to a Morning Call report.